At the meeting in Memphis, the NK cell function assay was described as not specific or useful because it gives an abnormal result whenever there is fever. Are most people still ordering the assay? Do people use instead a flow assay for NK cell perforin and/or CD107alpha instead (as mentioned in UpToDate)?
Perhaps people choose different tests for different kinds of HLH, as the Hscore for adults seems to not require NK cell activity (Fardet et al, 2014).
Thanks so much!
Office: +1 (856) 589-6606Fax: +1 (856) 589-6614Email: firstname.lastname@example.org
332 N Broadway
Pitman, NJ 08071 USA